KUKACLOX
Ampicillin Trihydrate
250mg + Cloxacillin Sodium 250mg
#Ampicillin: Ampicillin is a beta-lactam antibiotic
that is part of the aminopenicillin family and is roughly equivalent to
its successor, amoxicillin in terms of spectrum and level of activity.
Indication:
Ampicillin + Cloxacillin is used for the
treatment of infections of the respiratory tract, ear, nose and throat, GI
tract, skin and soft tissue, septicemia and endocarditis, General surgery,
gynaecological and obstetric surgery.
Respiratory
tract infections:
Upper
respiratory tract infections
Common upper respiratory tract
infections include:
- the common cold
- tonsillitis (infection of the tonsils and tissues at the back of the throat)
- sinusitis (infection of the sinuses)
- laryngitis (infection of the larynx, or voice box)
- flu
A cough is the
most common symptom of an upper RTI. Other symptoms include headaches,
a stuffy or runny nose, a sore throat,
sneezing and muscle aches.
Lower
respiratory tract infections
Common lower RTIs include:
- flu (this can affect either the upper or lower respiratory tract)
- bronchitis (infection of the airways)
- pneumonia (infection of the lungs)
- bronchiolitis (an infection of the small airways that affects babies and children younger than two)
- tuberculosis (persistent bacterial infection of the lungs)
The main symptom of a lower RTI is
also a cough, although it is usually more severe and you may bring up phlegm
and mucus. Other possible symptoms are a tight feeling in your chest, increased
rate of breathing, breathlessness
and wheezing.
PHARMACOLOGICAL ACTION:
(a) Bacteriology:
KUKACLOX exhibits in vivo and in vitro bactericidal activity against Gram-positive and Gram-negative organisms.
In vitro sensitivity does not necessarily imply in vivo activity.
(b) Absorption:
Both ampicillin and cloxacillin are acid stable and well absorbed orally, giving peak serum levels about two hours after dosing. As there is a linear dose/response in peak serum level after oral administration of both components, doubling the dose virtually doubles the peak serum levels.
(c) Excretion:
Both components are excreted primarily by the kidneys by glomerular filtration and tubular secretion.
Bile: Bile concentrations of KUKACLOX vary from 3 –48 times the serum concentration, according to the condition of the biliary tract.
(d) Probenecid:
Higher KUKACLOX serum levels can be achieved in patients with normal renal function by the concurrent administration of a renal blocking agent such as probenecid. In adults, a dose of 500 mg of probenecid q.d.s. will result in 1,5 –2 fold increase in KUKACLOX serum levels.
(a) Bacteriology:
KUKACLOX exhibits in vivo and in vitro bactericidal activity against Gram-positive and Gram-negative organisms.
In vitro sensitivity does not necessarily imply in vivo activity.
(b) Absorption:
Both ampicillin and cloxacillin are acid stable and well absorbed orally, giving peak serum levels about two hours after dosing. As there is a linear dose/response in peak serum level after oral administration of both components, doubling the dose virtually doubles the peak serum levels.
(c) Excretion:
Both components are excreted primarily by the kidneys by glomerular filtration and tubular secretion.
Bile: Bile concentrations of KUKACLOX vary from 3 –48 times the serum concentration, according to the condition of the biliary tract.
(d) Probenecid:
Higher KUKACLOX serum levels can be achieved in patients with normal renal function by the concurrent administration of a renal blocking agent such as probenecid. In adults, a dose of 500 mg of probenecid q.d.s. will result in 1,5 –2 fold increase in KUKACLOX serum levels.
KUKACLOX IS MARKETED BY:
KUKA PHARMACEUTICALS NIG.. LTD.
7/9, Sawyer Crescent, Phase 1,
Gbagada, Estate
Lagos.
http://www.kch.com.ng
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